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Clostripain

Clostripain also known as Clostridiopeptidase B or Endoproteinase Arg-C is a proteinase that cleaves peptide bonds on the carboxyl side of arginine. This protein is a heterodimer composed of a heavy and a light chain that are held together via strong noncovalent forces. As a proteolytic enzyme it can be used for isolation of various cell types by tissue dissociation.

Clostripain exists in two different forms, an oxidized, native condition and a reduced activated form that differ in enzymatic activity. The native clostripain can be activated with reducing agents (e.g. DTT, Cysteine) resulting in a higher activity of the enzyme.

Crescent Chemical Co., Inc. supplies NORDMARK CLOSTRIPAIN NB.
Click here for Clostripain NB Product Notes

Clostripain, the Missing Link in the Enzyme Blend for Efficient Human Islet Isolation
2017 - IPITA Islet Isolation
Synergistic Effect of Neutral Protease and Clostripain on Rat Pancreatic Islet Isolation

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